Levonorgestrel Silastic subcutaneous Implant Contraceptive Product

Usage and Dosage: Within the first week of the menstrual cycle (from the first day of menstruation), a 0.2cm incision was made on the skin of the upper arm or medial thigh under local anesthesia and the implant was placed under the skin with a trocar needle. Apply a band-aid and bandage with gauze. Two pills per person for four years.

Pharmacological action: Levonorgestrel (LNG) as the synthetic potent progesterone, mainly effect in the hypothalamus and pituitary, making middle menstruation follicle stimulating hormone (FSH) and luteinizing hormone (LH) significantly reduced or disappeared, the ovaries don't ovulate, has significant anti-estrogen activity. It thickens the cervical mucus and prevents sperm from penetrating. It shows strong progesterone activity in the transformation of the endometrium, which can thin the endometrium, make the epithelial cells of the endometrium appear low columnar, and have poor secretion function, which is not conducive to the implantation of fertilized eggs. Levonorgestrel also has certain androgenic activity and protein assimilation effects, and oral or subcutaneous injection can inhibit ovulation.

Long term release mechanism: The The main ingredient of Levonorgestrel Silastic subcutaneous Implant Contraceptive Product is levonorgestrel. is composed of two 4.4cm long and 2.4mm diameter silicone rods containing 75mg of Levonorgestrel. It can be used as a contraceptive for four years after implantation, and is zero release type implanted under the skin.
Two types of skin embedding agents are made by mixing drugs and carrier silicone rubber in a 1:1 ratio, vulcanizing them into rod-shaped drug cores, and then inserting the drug cores into thinner silicone tubes, sealing them with adhesive.

Due to the loose network structure of the molecules in the silicone tube, smaller drug molecules are allowed to diffuse out of the pores, thereby achieving sustained release. The process of drug diffusion from the drug core to the silicone tube, and then release from the silicone tube into the bloodstream is called double release. When drugs enter the bloodstream through the tube wall, they produce corresponding pharmacological effects.